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Contributor Information

  • Institute Yale University

Tool Details

  • Tool name: Anti-CD3 [C363.29B]
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Rat
  • Description: Monoclonal antibody which binds an epitope within the CD3-TCR complex. Background and Research Application The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3?, CD3? and 2X CD3?), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex.
  • Immunogen: P07766
  • Immunogen UniProt ID: P07766
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: CD3
  • Target background: Monoclonal antibody which binds an epitope within the CD3-TCR complex. Background and Research Application The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3Î?, CD3δ and 2X CD3?), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex.

Application Details

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176.
  •   Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436.
  •   Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202.
  •   Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.