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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD3 [PC3/188A] mAb
  • Alternate names: T3 complex
  • Clone: PC3/188A
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Chicken ; Horse ; Guinea Pig ; Opossum ; Pig ; Primate ; Rat ; Rabbit
  • Host: Mouse
  • Application: IHC ; WB
  • Description: PC3/188A also detects CD3 in mammalian tissues.
  • Immunogen: Peptide sequence (156-168) from the intracytoplasmic portion of the epsilon-chain of CD3
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CD3
  • Target background: The CD3 complex, composed of five CD3 polypeptide chains, associates with the T cell antigen receptor (TCR) and is found on all mature human T lymphocytes. CD3 can be used for the identification of normal and malignant T lymphocytes in paraffin embedded or frozen tissue sections.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Doursout et al. 2013. J Interferon Cytokine Res. 33(7):376-83. PMID: 23600861.
  • •  Inflammatory cells and cytokines in the olfactory bulb of a rat model of neuroinflammation
  • •  insights into neurodegeneration?
  • •  Wang et al. 2012. PLoS One. 7(7):e39525. PMID: 22848356.
  • •  Interleukin-10 haplotype may predict survival and relapse in resected non-small cell lung cancer.
  • •  Bianchi et al. 2012. Diabetes Metab Res Rev. 28(2):156-63. PMID: 21922635.
  • •  Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin-induced diabetes.
  • •  Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
  • •  Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.