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Contributor Information

  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-AvW-3 [AvW-3]
  • Alternate names: vWf
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 250 kDa
  • Application: ELISA ; IP
  • Description: Von Willebrand factor (vWF) is a multimeric plasma glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.
  • Immunogen: vWF (A1 domain of mature vWF)
  • Research area: Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: von Willebrand Factor
  • Target molecular weight: 250 kDa
  • Target background: Von Willebrand factor (vWF) is a multimeric plasma glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.

Application Details

  • Application: ELISA ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Jacobi et al. 2012. Blood. 119(19):4543-53. PMID: 22431572.
  • •  Zhao et al. 2007. J Thromb Haemost. 5(9):1963-70. PMID: 17723136.
  • •  Rosenberg et al. 2002. Blood. 100(5):1699-706. PMID: 12176890.
  • •  Nakayama et al. 2002. J Biol Chem. 277(24):22063-72. PMID: 11943773.
  • •  Hillery et al. 1998. Blood. 91(5):1572-81. PMID: 9473222.
  • •  Mancuso et al. 1996. Blood. 88(7):2559-68. PMID: 8839848.
  • •  Scott et al. 1991. Am J Clin Pathol. 96(6):723-8. PMID: 1746488.
  • •  Kawai et al. 1987. Ann N Y Acad Sci. 509:60-70. PMID: 3122620.