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Contributor Information

  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-AvW-1 (von Willebrand Factor) [A8-1]
  • Alternate names: vWf
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 250 kDa
  • Application: ELISA ; IF ; IP ; WB
  • Description: von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.
  • Immunogen: vWF (COOH terminus of mature vWF)
  • Research area: Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: von Willebrand Factor
  • Target molecular weight: 250 kDa
  • Target background: von Willebrand factor (vWF) is a multimeric glycoprotein that functions in hemostasis as the initiator of platelet adhesion at the site of vascular injury and as the carrier of the anti-hemophilic factor, factor VIII (FVIII). Hereditary or acquired defects of VWF lead to von Willebrand disease (vWD), a bleeding diathesis of the skin and mucous membranes, causing nosebleeds, menorrhagia, and gastrointestinal bleeding.

Application Details

  • Application: ELISA ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Flood et al. 2018. Res Pract Thromb Haemost. 2(2):390-398. PMID: 30046743.
  • •  Haberichter et al. 2008. Blood. 111(10):4979-85. PMID: 18344424.
  • •  Rosenberg et al. 2002. Blood. 100(5):1699-706. PMID: 12176890.
  • •  Hillery et al. 1998. Blood. 91(5):1572-81. PMID: 9473222.
  • •  Rosenberg et al. 1998. J Clin Invest. 101(3):613-24. PMID: 9449695.
  • •  Scott et al. 1991. Am J Clin Pathol. 96(6):723-8. PMID: 1746488.
  • •  Kroner et al. 1991. J Biol Chem. 266(29):19146-9. PMID: 1918030.
  • •  Montgomery et al. 1986. Methods Enzymol. 121:702-17. PMID: 3724493.
  • •  Schullek et al. 1984. J Clin Invest. 73(2):421-8. PMID: 6230372.