ANTIBODIES
Contributor Information
- Name Lindy Durrant
- Institute University of Nottingham
Tool Details
- Tool name: Anti-MUC2 [994/152]
- Clone: 994/152
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Cancer type: Digestive / Gastrointestinal cancer;
- Application: IHC ; ELISA ; IHC
- Description: Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. MUC2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogenous and exogenous lectins.
- Immunogen: A peptide based on the tandem repeat sequence of MUC2
- Isotype: IgG1
- Research area: Cancer; Cell biology; Cell signaling and signal transduction
- Myeloma used: NS0
- For Research Use Only
Target Details
- Target: Mucin2 (MUC2)
- Target background: Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. MUC2 is the major intestinal mucin. O-glycans are attached to MUC2 in a potentially diverse arrangement, which is crucial for their interaction with endogenous and exogenous lectins.
Application Details
- Application: IHC ; ELISA ; IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Gold et al. 2013. Mol Cancer. 12(1):143. PMID: 24257318.
- • Mapping PAM4 (clivatuzumab), a monoclonal antibody in clinical trials for early detection and therapy of pancreatic ductal adenocarcinoma, to MUC5AC mucin.
- • Durrant et al. 1994. Eur J Cancer. 30A(3):355-63. PMID: 8204359.
- • Production of monoclonal antibodies recognising the peptide core of MUC2 intestinal mucin.
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