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Contributor Information

  • Institute Absolute Antibody; University of Oxford

Tool Details

  • Tool name: Anti-CD79b [B29/123] rAb
  • Alternate names: CD79b Molecule; CD79B Antigen (Immunoglobulin-Associated Beta); Immunoglobulin-Associated B29 Protein; B-Cell-Specific Glycoprotein B29; Ig-Beta
  • Clone: B29/123
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Blood cancer
  • Description: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling.
  • Immunogen: Synthetic peptide representing the c-terminus from residue 215 of the murine B29 polypeptide.
  • Isotype: IgG2b
  • Research area: Cell signaling and signal transduction; Immunology

  • For Research Use Only

Target Details

  • Target: CD79b
  • Target background: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4° C

Documentation

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References

  • •  A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
  • •  Broad feedback inhibition of pre-B-cell receptor signaling components.
  • •  Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.
  • •  Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
  • •  Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.
  • •  Hauser et al. 2013. Mol Immunol. 54(3-4):247-53. PMID: 23318223.
  • •  Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
  • •  Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.
  • •  Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
  • •  Ouchida et al. 2010. J Immunol. 185(1):294-301. PMID: 20519653.
  • •  The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
  • •  The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.