Product Image

Contributor Information

  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD44v3 [3G5]
  • Alternate names: CD44 Molecule; Hematopoietic Cell E- And L-Selectin Ligand; GP9 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CSPG8; HCELL; PGP-1; MC56; Pgp1
  • Clone: 3G5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IP ; WB
  • Description: Monoclonal antibody directed against a marker of tumour metastasis.
  • Immunogen: Human chimeric fusion protein CD44v3-10-Fc
  • Immunogen UniProt ID: P16070
  • Isotype: IgG2b
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: CD44v3-10-Fc
  • Target background: CD44 is an integral cell membrane glycoprotein that binds to hyaluronan and is involved in matrix adhesion, lymphocyte activation, and lymph node homing. CD44 is expressed on multiple cell types and is involved in multiple functions including cell-cell interactions and cell-extracellular matrix binding. The CD44 protein is expressed as a family of molecular isoforms generated from alternative RNA splicing and posttranslational modifications. This antibody recognizes an epitope encoded by exon v3 on the variant portion of human CD44.

Application Details

  • Application: ELISA ; FACS ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Sufu

#153541
Product Image

Anti-VSV-N [10G4]

#153812
Product Image

Anti-CHIKV [11E7]

#153201

References

  • •  Yoo et al. 2016. Proc Natl Acad Sci U S A. :. PMID: 27872288.
  • •  MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis.
  • •  Liu et al. 2014. Asian Pac J Cancer Prev. 15(12):5049-53. PMID: 24998585.
  • •  Fox et al. 1994. Cancer Res. 54(16):4539-46. PMID: 7519124.
  • •  Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.