ANTIBODIES

Contributor Information
- Institute Absolute Antibody; University of Oxford
Tool Details
- Tool name: Anti-CD79a [HM57] rAb
- Alternate names: CD79a Molecule; Membrane-Bound Immunoglobulin-Associated Protein; Surface IgM-Associated Protein; MB-1 Membrane Glycoprotein; Ig-Alpha; IGA; CD79a Antigen; MB1
- Clone: HM57
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Recombinant
- Conjugate: Unconjugated
- Reactivity: Bovine ; Chicken ; Horse ; Human ; Guinea Pig ; Mouse ; Opossum ; Pig ; Primate ; Rat ; Rabbit
- Host: Mouse
- Cancer type: Blood cancer
- Description: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.
- Immunogen: Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence.
- Isotype: IgG1
- Research area: Cancer; Cell signaling and signal transduction; Immunology; Stem cell biology
- For Research Use Only
Target Details
- Target: CD79a (mb1)
- Target background: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.
Application Details
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4° C
Related Tools
References
- • CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.
- • Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
- • Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
- • Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.
- • Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
- • Mason et al. 1995. Blood. 86(4):1453-9. PMID: 7632952.
- • The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
- • The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.
- • The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.
- • van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.