ANTIBODIES

Contributor Information
- Institute Ohio State University
Tool Details
- Tool name: Anti-Cereblon [3B12F7]
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Host: Mouse
- Molecular weight of the target: 51 kDa
- Application: WB ; IHC
- Description: Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia. Cereblon protein is known to bind calcium-activated potassium channels (KCNMA1 subtype) and mutations in the CRBN gene are linked to cognitive defects, including intellectual disability. Cereblon also interacts with E3 ubiquitin ligase and may play a key role in limb outgrowth in embryos.
- Immunogen: Peptide corresponding to sequence near the N-terminus of human cereblon
- Immunogen UniProt ID: CRBN_HUMAN
- Research area: Cancer; Neurobiology
- For Research Use Only
Target Details
- Target: Cereblon
- Target molecular weight: 51 kDa
- Target background: Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia. Cereblon protein is known to bind calcium-activated potassium channels (KCNMA1 subtype) and mutations in the CRBN gene are linked to cognitive defects, including intellectual disability. Cereblon also interacts with E3 ubiquitin ligase and may play a key role in limb outgrowth in embryos.
Application Details
- Application: WB ; IHC
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC