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Contributor Information

  • Institute Absolute Antibody; University of Oxford

Tool Details

  • Tool name: Anti-CD21L [R4/23] rAb
  • Alternate names: Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2
  • Clone: R4/23
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: WB
  • Description: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the “Long” isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
  • Immunogen: Cell lysate from a chronic lymphocytic leukemia patient.
  • Isotype: IgM
  • Research area: Cell biology; Immunology

  • For Research Use Only

Target Details

  • Target: Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
  • Target background: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the Long isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.
  • •  Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.
  • •  Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.
  • •  Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
  • •  Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.
  • •  Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.
  • •  Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
  • •  Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.