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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-MHC class II HLA-DQ [SPVL3]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Pig
  • Host: Mouse
  • Application: FACS ; IHC ; IP
  • Strain: Balb/c
  • Description: HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an Î?Î? heterodimer of type MHC class II. The Î? and Î? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both Î?-chain and Î?-chain vary greatly. A person often produces two Î?-chain and two Î?-chain variants and thus 4 isoforms of DQ.
  • Immunogen: Cloned cytotoxic T lymphocytes.
  • Isotype: IgG2a
  • Research area: Cell signaling and signal transduction; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: MHC class II HLA-DQ
  • Target background: HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an a? heterodimer of type MHC class II. The a and ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both a-chain and ?-chain vary greatly. A person often produces two a-chain and two ?-chain variants and thus 4 isoforms of DQ.

Application Details

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117.
  • •  Spits et al. 1984. Eur J Immunol. 14(4):299-304. PMID: 6609821.
  • •  Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.