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Contributor Information

  • Name Richard Marais
  • Institute The Institute of Cancer Research

Tool Details

  • Tool name: Anti-cMyc [JAC6]
  • Alternate names: Myc proto oncogene protein; c Myc
  • Clone: JAC6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rat
  • Cancer type: Gynaecologic cancer; Digestive / Gastrointestinal cancer; Breast cancer; Lung
  • Molecular weight of the target: 53 kDa
  • Application: IHC ; IF ; IP ; WB
  • Description: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
  • Immunogen: Synthetic peptide, corresponding to amino acids 408-439 of Human c-Myc
  • Isotype: IgG1
  • Research area: Apoptosis and autophagy; Cancer; Cell biology; Immunology

  • For Research Use Only

Target Details

  • Target: myc
  • Target molecular weight: 53 kDa
  • Target background: Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Su et al. 2015. J Cell Sci. 128(22):4063-73. PMID: 26430213.
  • •  Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site.
  • •  von Philipsborn et al. 2014. Curr Biol. 24(3):242-51. PMID: 24440391.
  • •  Cellular and behavioral functions of fruitless isoforms in Drosophila courtship.
  • •  Coleman et al. 2011. J Biol Chem. 286(19):17205-16. PMID: 21454556.
  • •  Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2.
  • •  Ringli et al. 2010. Plant J. 63(4):662-9. PMID: 20545889.
  • •  The hydroxyproline-rich glycoprotein domain of the Arabidopsis LRX1 requires Tyr for function but not for insolubilization in the cell wall.
  • •  Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.
  • •  Bushell et al. 2009. PLoS Pathog. 5(8):e1000539. PMID: 19662167.
  • •  Fernando et al. 2008. Clin Cancer Res. 14(5):1529-39. PMID: 18316578.
  • •  Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.
  • •  Zavortink et al. 2005. J Cell Sci. 118(Pt 22):5381-92. PMID: 16280552.
  • •  Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.