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Contributor Information

  • Name Joy Burchell ; Joyce Taylor-Papadimitriou
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Casein [F20.14]
  • Clone: F20.14
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 28 kDa
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: F20.14 can be used as in vitro markers of terminally differentiated breast lumenal epithelial cells.
  • Immunogen: Purified casein and a-lactalbumin.
  • Isotype: IgG1
  • Research area: Cell biology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Casein beta subunit
  • Target molecular weight: 28 kDa
  • Target background: Caseins are the major proteins found in milk.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.88 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bonuccelli et al. 2012. Cell Cycle. 11(21):3972-82. PMID: 23047602.
  • •  The milk protein a-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.
  • •  Burchell et al. 1985. Hybridoma. 4(4):341-50. PMID: 3905581.
  • •  Production and characterization of monoclonal antibodies to human casein. A monoclonal antibody that cross-reacts with casein and alpha-lactalbumin.