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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-E2F4 [RK13]
  • Alternate names: E2F Transcription Factor 4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 62 kDa
  • Application: IHC ; IF ; IP ; WB
  • Description: E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumour suppressor proteins and is also a target of the transforming proteins of small DNA tumour viruses. This protein binds to all three of the tumour suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
  • Immunogen: Raised against amino acids 108-300 of E2F-4 of human origin
  • Isotype: IgG2a
  • Research area: Genetics

  • For Research Use Only

Target Details

  • Target: E2F-4
  • Target molecular weight: 62 kDa
  • Target background: E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumour suppressor proteins and is also a target of the transforming proteins of small DNA tumour viruses. This protein binds to all three of the tumour suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Bindra et al. 2007. Oncogene. 26(14):2048-57. PMID: 17001309.