ANTIBODIES
Contributor Information
- Name Itzhak Fischer
- Institute Drexel University
Tool Details
- Tool name: Anti-Big (high-molecular-weight) tau
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Rat
- Host: Rabbit
- Application: IHC ; WB
- Description: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great shear forces.
- Immunogen: Recombinant protein of the complete 4a exon of tau, specific to the Big tau isoform, was used to produce antibody
- Research area: Developmental biology; Neurobiology
- For Research Use Only
Target Details
- Target: Big tau (high-molecular-weight)
- Target background: Tau is a neuronal microtubule associated protein (MAP) which has multiple isoforms that are differentially expressed during development. Big tau is a high molecular weight isoform that contains an additional large exon (4a) and is expressed primarily by neurons in the peripheral nervous system. Big tau expression has also been shown in the developing spinal cord and in the adult central nervous system. Big tau may be important in stabilizing microtubules in axons that are subjected to great shear forces.
Application Details
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Boyne et al. 1995. J Comp Neurol. 358(2):279-93. PMID: 7560287.
- • Distribution of Big tau in the central nervous system of the adult and developing rat.
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