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Contributor Information

  • Institute University of Maryland

Tool Details

  • Tool name: Anti-RAP [7F1]
  • Alternate names: Receptor Associated Protein antibody
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 39 kDa
  • Application: WB ; IHC ; ELISA
  • Description: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1.
  • Immunogen: human RAP
  • Isotype: IgG1
  • Research area: Genetics; Cell signaling and signal transduction; Neurobiology

  • For Research Use Only

Target Details

  • Target: 39-kDa receptor-associated protein (RAP)
  • Target molecular weight: 39 kDa
  • Target background: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Fnly, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1.

Application Details

  • Application: WB ; IHC ; ELISA

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Coukos et al. 1994. Am J Pathol. 144(2):383-92. PMID: 7508685.
  •   Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts.