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Contributor Information

  • Name Lawrence Banks
  • Institute International Centre For Genetic Engineering And Biotechnology (ICGEB)

Tool Details

  • Tool name: Anti-p53
  • Alternate names: Tumour Protein p53, Cellular Tumour Antigen p53, Phosphoprotein p53, Antigen NY-CO-13
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Cancer type: Broadly Applicable
  • Molecular weight of the target: 53 kDa
  • Application: IF ; IP ; WB
  • Description: Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage.
  • Immunogen: C-terminal 14 amino acids of human p53
  • Research area: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: p53
  • Target molecular weight: 53 kDa
  • Target background: p53 has been described as the 'guardian of the genome' because of its role in conserving stability by preventing genome mutation. The TP53 gene is the most frequently mutated gene (>50%) in human cancer.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: Serum
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Thomas et al. 1999. Mol Cell Biol. 19(2):1092-100. PMID: 9891044.
  • •  Two polymorphic variants of wild-type p53 differ biochemically and biologically.
  • •  Thomas et al. 1996. Oncogene. 13(3):471-80. PMID: 8760288.
  • •  HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.