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Contributor Information

  • Name Alison Banham
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-FMIP [F6D/11]
  • Clone: F6D/11
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Description: Fms interacting protein (FMIP) is a substrate, as well as a binding partner, of Fms tyrosine kinase. FMIP is a ubiquitous nuclear/cytoplasm shuttling protein with a leucine zipper. The overexpression of FMIP in myeloid progenitor cells alters the macrophage colony stimulating factor (M-CSF)-mediated macrophage differentiation. These cells differentiate into the granulocytic lineage rather than into the macrophage lineage. Furthermore, it has been shown that FMIP is one of the major molecules phosphorylated via the insulin-mediated signaling pathway in a preadipocyte cell line, 3T3-L1 cells, suggesting that FMIP may play a role in adipocyte differentiation.
  • Immunogen: C-terminus of the human FMIP protein as a glutathione-S-transferase (GST) fusion protein
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction; Cell biology; Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Fms interacting protein (FMIP)
  • Target background: Fms interacting protein (FMIP) is a substrate, as well as a binding partner, of Fms tyrosine kinase. FMIP is a ubiquitous nuclear/cytoplasm shuttling protein with a leucine zipper. The overexpression of FMIP in myeloid progenitor cells alters the macrophage colony stimulating factor (M-CSF)-mediated macrophage differentiation. These cells differentiate into the granulocytic lineage rather than into the macrophage lineage. Furthermore, it has been shown that FMIP is one of the major molecules phosphorylated via the insulin-mediated signaling pathway in a preadipocyte cell line, 3T3-L1 cells, suggesting that FMIP may play a role in adipocyte differentiation.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Guria et al. 2011. RNA. 17(6):1048-56. PMID: 21525145.
  • •  Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.
  • •  Mancini et al. 2010. BMC Biol. 8:1. PMID: 20051105.
  • •  THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
  • •  Mancini et al. 2007. Oncogene. 26(7):1020-7. PMID: 16909111.
  • •  FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.