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Contributor Information

  • Name Richard Aster
  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-Integrin Beta 3a (GPIIIa, CD61) [AP-3]
  • Alternate names: CD-61
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Molecular weight of the target: ~ 86-87 kDa
  • Application: ELISA ; FACS
  • Description: Monoclonal antibody specific for human glycoprotein IIIa. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. This antibody is specific for amino acids 50-62 of GP11a.
  • Immunogen: Human platelet
  • Immunogen UniProt ID: P05106
  • Isotype: IgG1
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: Integrin Beta 3a (GPIIIa, CD61)
  • Target molecular weight: ~ 86-87 kDa
  • Target background: Monoclonal antibody specific for human glycoprotein IIIa. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Glycoprotein IIb/IIIa, also known as integrin aIIb?3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. This antibody is specific for amino acids 50-62 of GP11a.

Application Details

  • Application: ELISA ; FACS

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.
  • •  Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.
  • •  Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.