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Contributor Information

  • Name Vincent Harley
  • Institute Hudson Institute Of Medical Research

Tool Details

  • Tool name: Anti-SOX9
  • Alternate names: SOX9, CMPD1, CMD1, SRA1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Chicken ; Human ; Mouse ; Rabbit
  • Host: Rabbit
  • Cancer type: Lung; Genitourinary cancer; Pancreatic cancer; Liver cancer; Bile duct cancer; Digestive / Gastrointestinal cancer; Gastric
  • Application: ChIP ; IF ; WB
  • Description: The Sox genes are a family of genes related to the mammalian sex determining gene ex-determining region Y protein (SRY). SOX genes genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators which have been implicated in the process of development and cell fate. At present 30 Sox genes have been identified and members of the family are conserved during evolution. Transcription factor SOX9 recognizes the sequence "CCTTGAG" as do other members of the high mobility group-box class DNA-binding proteins.
  • Immunogen: Synthetic Human SOX9 peptide
  • Research area: Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: SOX9
  • Target background: The Sox genes are a family of genes related to the mammalian sex determining gene ex-determining region Y protein (SRY). SOX genes genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators which have been implicated in the process of development and cell fate. At present 30 Sox genes have been identified and members of the family are conserved during evolution. Transcription factor SOX9 recognizes the sequence "CCTTGAG" as do other members of the high mobility group-box class DNA-binding proteins.

Application Details

  • Application: ChIP ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4° C

Documentation

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References

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  • •  Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis.
  • •  Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve.
  • •  Balakrishnan et al. 2016. PLoS One. 11(4):e0153256. PMID: 27058953.
  • •  Krah et al. 2015. Elife. 4:. PMID: 26151762.
  • •  The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
  • •  Xu et al. 2014. EMBO J. 33(19):2157-70. PMID: 25107471.
  • •  Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.
  • •  Morais da Silva et al. 1996. Nat Genet. 14(1):62-8. PMID: 8782821.
  • •  Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds.