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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Myelin Basic Protein (region Thr98) [98/P12]
  • Alternate names: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
  • Clone: 98/P12
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Neurological cancer
  • Molecular weight of the target: 13-21 kDa
  • Application: ELISA ; WB
  • Description: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
  • Immunogen: Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
  • Isotype: IgG2a
  • Research area: Cell biology; Immunology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Myelin Basic Protein (region Thr98)
  • Target molecular weight: 13-21 kDa
  • Target background: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.
  •   Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.
  •   DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.
  •   Developmental partitioning of myelin basic protein into membrane microdomains.
  •   Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.
  •   Regulation of myelin basic protein phosphorylation by mitogen-activated protein kinase during increased action potential firing in the hippocampus.
  •   Yon et al. 1996. J Neuroimmunol. 65(1):55-9. PMID: 8642064.
  •   Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.
  •   Yon et al. 1995. J Neuroimmunol. 58(2):121-9. PMID: 7759601.
  •   Preparation of a novel monoclonal antibody specific for myelin basic protein phosphorylated on Thr98.