ANTIBODIES

Contributor Information
- Institute BioServ UK Ltd
Tool Details
- Tool name: Anti-Myelin Basic Protein (region Thr98) [98/P12]
- Alternate names: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
- Clone: 98/P12
- Tool type: Antibodies
- Tool sub-type: Primary Antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Cancer type: Neurological cancer
- Molecular weight of the target: 13-21 kDa
- Application: ELISA ; WB
- Description: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
- Immunogen: Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
- Isotype: IgG2a
- Research area: Cell biology; Immunology; Neurobiology
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: Myelin Basic Protein (region Thr98)
- Target molecular weight: 13-21 kDa
- Target background: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
Application Details
- Application: ELISA ; WB
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4ðC
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References
- • DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.
- • Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.
- • DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.
- • Developmental partitioning of myelin basic protein into membrane microdomains.
- • Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.
- • Regulation of myelin basic protein phosphorylation by mitogen-activated protein kinase during increased action potential firing in the hippocampus.
- • Yon et al. 1996. J Neuroimmunol. 65(1):55-9. PMID: 8642064.
- • Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.
- • Yon et al. 1995. J Neuroimmunol. 58(2):121-9. PMID: 7759601.
- • Preparation of a novel monoclonal antibody specific for myelin basic protein phosphorylated on Thr98.