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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Myelin Basic Protein (region 129-138) [MBP1]
  • Alternate names: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
  • Clone: MBP1
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Rat
  • Host: Mouse
  • Cancer type: Neurological cancer
  • Molecular weight of the target: 13-21 kDa
  • Application: ELISA ; IHC ; WB
  • Description: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves. MBP Clone 1 recognizes an epitope in the 129-138 region of MBP, useful in clinical diagnosis to detect MBP levels.
  • Immunogen: Reacts with MBP from human, bovine and rat, recognizing epitope 129-138
  • Isotype: IgG2a
  • Research area: Cell biology; Immunology; Neurobiology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Myelin Basic Protein (region 129-138)
  • Target molecular weight: 13-21 kDa
  • Target background: Myelin Basic Protein (MBP) is involved in the process of myelination of nerves. MBP Clone 1 recognizes an epitope in the 129-138 region of MBP, useful in clinical diagnosis to detect MBP levels.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Marignier et al. 2010. Brain. 133(9):2578-91. PMID: 20688809.
  • •  Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
  • •  Jatana et al. 2006. Pediatr Res. 59(5):684-9. PMID: 16627882.
  • •  Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats.
  • •  Chujor et al. 1991. Int J Lepr Other Mycobact Dis. 59(4):590-7. PMID: 1724981.
  • •  Serum antibodies against peripheral nervous system antigens in leprosy.
  • •  Brunner et al. 1989. J Neurochem. 52(1):296-304. PMID: 2462020.
  • •  Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase in the CNS of adult rats.
  • •  Groome et al. 1986. J Neuroimmunol. 12(4):253-64. PMID: 2428830.
  • •  Region-specific immunoassays for human myelin basic protein.
  • •  Groome et al. 1985. Neurochem Int. 7(2):309-17. PMID: 20492929.
  • •  Preparation and properties of monoclonal antibodies to myelin basic protein and its peptides.