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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Follistatin 288 [17-2]
  • Alternate names: Follistatin, FS, FST, Active-binding protein
  • Clone: [17-2]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 37 kDa
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. Clone 17/2 recognizes recombinant human Follistatin 288, allowing for detection of FSH levels using various analysis methods. This antibody also works in a two site ELISA with Clone 29/9.
  • Immunogen: Recognizes human Follistatin isoform FS288, raised against recombinant human FS288
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction; Genetics; Immunology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Follistation 288
  • Target molecular weight: 37 kDa
  • Target background: Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. Clone 17/2 recognizes recombinant human Follistatin 288, allowing for detection of FSH levels using various analysis methods. This antibody also works in a two site ELISA with Clone 29/9.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Hands et al. 2013. Anal Bioanal Chem. 405(23):7347-55. PMID: 23831829.
  • •  Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors.
  • •  Fitzgerald et al. 2012. Invest Ophthalmol Vis Sci. 53(11):7358-69. PMID: 23010638.
  • •  The effects of transforming growth factor-?2 on the expression of follistatin and activin A in normal and glaucomatous human trabecular meshwork cells and tissues.
  • •  Mabuchi et al. 2006. Oncol Rep. 15(2):291-6. PMID: 16391844.
  • •  Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma.
  • •  Pratic et al. 2004. Chem Phys Lipids. 128(1-2):165-71. PMID: 15037161.
  • •  F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.
  • •  Evans et al. 1998. J Endocrinol. 156(2):275-82. PMID: 9518873.
  • •  Development, validation and application of an ultra-sensitive two-site enzyme immunoassay for human follistatin.
  • •  Majdic et al. 1997. Endocrinology. 138(5):2136-47. PMID: 9112414.
  • •  Testicular expression of inhibin and activin subunits and follistatin in the rat and human fetus and neonate and during postnatal development in the rat.