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Contributor Information

  • Institute BioServ UK Ltd

Tool Details

  • Tool name: Anti-Estrogen Receptor Beta1 [PPG5/10]
  • Alternate names: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
  • Clone: PPG5/10
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Pig ; Primate ; Rat ; Sheep ; Rhesus macaque ; Cynomolgus monkey ; Turtle ; Goose
  • Host: Mouse
  • Cancer type: Gynaecologic cancer; Breast cancer;
  • Molecular weight of the target: 59 kDa
  • Application: IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/10 recognizes Estrogen Receptor Beta (ERÎ?) 1 and is useful in determining the expression of ERÎ?1 in cancer cells, mainly via immunohistochemistry.
  • Immunogen: Synthetic peptide CEDSKSKEGSQNPQSQ derived from the C terminus of human ER?1
  • Isotype: IgG2a
  • Research area: Cancer; Immunology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Estrogen Receptor ?1
  • Target molecular weight: 59 kDa
  • Target background: Estrogen receptors are commonly over-expressed in cancers. Clone PPG5/10 recognizes Estrogen Receptor Beta (ER?) 1 and is useful in determining the expression of ER?1 in cancer cells, mainly via immunohistochemistry.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Zannoni et al. 2016. Histopathology. 68(4):541-8. PMID: 26132417.
  • •  Sexual dimorphism in medulloblastoma features.
  • •  Gender effect in experimental models of human medulloblastoma: does the estrogen receptor ? signaling play a role?
  • •  Ciucci et al. 2014. PLoS One. 9(7):e101623. PMID: 25000562.
  • •  Asgari et al. 2011. Diagn Pathol. 6:61. PMID: 21733187.
  • •  Estrogen receptor beta expression in prostate adenocarcinoma.
  • •  Collins et al. 2009. BMC Cancer. 9:330. PMID: 19758455.
  • •  Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.
  • •  Schiessl et al. 2005. J Histochem Cytochem. 53(12):1441-9. PMID: 15983116.
  • •  Wong et al. 2005. J Pathol. 207(1):53-60. PMID: 15954165.
  • •  ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.
  • •  Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies.
  • •  Sierens et al. 2004. J Mol Endocrinol. 32(3):703-18. PMID: 15171710.
  • •  Cloning of oestrogen receptor beta from Old and New World primates: identification of splice variants and Fn analysis.
  • •  Torlakovic et al. 2002. Hum Pathol. 33(6):646-51. PMID: 12152165.
  • •  Prostate carcinoma expression of estrogen receptor-beta as detected by PPG5/10 antibody has positive association with primary Gleason grade and Gleason score.