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Contributor Information

  • Name Thomas Decker
  • Institute University of Vienna

Tool Details

  • Tool name: Anti-Stat1Alpha-C
  • Alternate names: STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
  • Tool type: Antibodies
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Application: IP
  • Description: In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.
  • Immunogen: GST fusion protein comprising the 39 C-terminal amino acids of Stat1a
  • Research area: Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: C terminus of signal transducer and activator of transcription 1
  • Target background: In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by several ligands such as Interferon alpha, Interferon gamma, Platelet Derived Growth Factor, Interleukin 6 or Epidermal Growth Factor. STAT1 has a key role in expressing many genes involved in survival of the cell, viability or pathogen response. Through alternative splicing there are two possible transcripts which encode 2 isoforms of STAT1. The compound, diallyl disulphide, found in garlic can induce STAT1 phosphorylation.

Application Details

  • Application: IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Kovarik, P., Stoiber, D., Novy, M. & Decker, T. (1998) EMBO J. 17, 3660–3668