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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-TRF2 [SWE38]
  • Clone: SWE38
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rabbit
  • Application: ChIP ; IF ; WB
  • Description: TRF2 (also known as TERF2), is a component of the telomere nucleoprotein complex. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes.
  • Immunogen: His tagged full length recombinant TRF2 (from baculovirus)
  • Research area: Cancer; Genetics

  • For Research Use Only

Target Details

  • Target: human TRF2
  • Target background: TRF2 (also known as TERF2), is a component of the telomere nucleoprotein complex. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes.

Application Details

  • Application: ChIP ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: Whole serum
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Tarsounas et al. 2004. Cell. 117(3):337-47. PMID: 15109494.
  • •  Telomere maintenance requires the RAD51D recombination/repair protein.
  • •  Tarsounas et al. 2003. Oncogene. 22(8):1115-23. PMID: 12606939.
  • •  BRCA2-dependent and independent formation of RAD51 nuclear foci.