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Contributor Information

  • Institute University of Reading

Tool Details

  • Tool name: Anti-CD195 [HEK/1/85a/7a]
  • Alternate names: Anti-CCR5, CCR5 Antibody, CD195 Antibody, C-C chemokine receptor type 5, HIV-1 fusion co-receptor
  • Clone: HEK/1/85a/7a
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Rat
  • Application: FACS ; IF ; Fn
  • Description: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
  • Immunogen: CHO cells transfected with human CCR5
  • Isotype: IgG2a kappa
  • Research area: Immunology; Microbiology
  • Myeloma used: Y3.AG.1.2.3

  • For Research Use Only

Target Details

  • Target: CD195
  • Target background: CD195 or CCR5 (CC-chemokine receptor type 5) is a receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. It may play a role in the control of granulocytic lineage proliferation or differentiation, and has been shown to act as a co-receptor for HIV-1 R5 isolates. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Application Details

  • Application: FACS ; IF ; Fn

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Mueller et al. 2002. Blood. 99(3):785-91. PMID: 11806977.
  • •  Pathways for internalization and recycling of the chemokine receptor CCR5.