ANTIBODIES
Contributor Information
- Name Keith Willison
- Institute The Institute of Cancer Research
Tool Details
- Tool name: Anti-VHL [LIZ167C]
- Alternate names: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Clone: LIZ/1/67c
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Description: VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. It is involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
- Research area: Cancer; Cell biology; Genetics; Metabolism
- For Research Use Only
Target Details
- Target: VHL
- Target background: VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. It is involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
Application Details
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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