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Contributor Information

  • Institute University of Maryland

Tool Details

  • Tool name: Anti-LRP1 [8G1]
  • Alternate names: LRP1, Low density lipoprotein receptor-related protein 1, apolipoprotein E receptor (APOER), cluster of differentiation 91 (CD91), alpha-2-macroglobulin receptor (A2MR)
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse ; Rat ; Human
  • Host: Mouse
  • Molecular weight of the target: 85/515/700 kDA
  • Application: IHC ; WB ; EM (EM) ; DB ; FACS
  • Description: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus.
  • Immunogen: full length LRP-1 protein
  • Isotype: IgG1
  • Research area: Genetics; Cell signaling and signal transduction; Neurobiology

  • For Research Use Only

Target Details

  • Target: Low density lipoprotein receptor-related protein-1, heavy chain
  • Target molecular weight: 85/515/700 kDA
  • Target background: LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Fnly, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus.

Application Details

  • Application: IHC ; WB ; EM (EM) ; DB ; FACS

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Strickland et al. 1990. J Biol Chem. 265(29):17401-4. PMID: 1698775.
  • •  Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multiFn receptor.