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Contributor Information

  • Name Irene Leigh
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Keratin 10 [LHP1]
  • Alternate names: CK 1 antibody, CK-1 antibody, Cytokeratin-1 antibody, EHK antibody, K1 antibody, K1C1_HUMAN antibody, Keratin 1 antibody, Keratin 1 type I antibody, Keratin antibody, Keratin type i cytoskeletal 1 antibody, Keratin type I cytoskeletal 59 kDa antibody, Keratin-1 antibody, Keratin1 antibody, KPP antibody, KRT1 antibody, type I cytoskeletal 1 antibody
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 1 and 10 are differentiation-specific keratins that are the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epithelia. Mutations in keratins 1 and 10 cause epidermolytic hyperkeratosis.
  • Immunogen: Epidermis from Psoriasis patient (crude extract)
  • Isotype: IgG1
  • Research area: Cancer; Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin 10
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 1 and 10 are differentiation-specific keratins that are the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epithelia. Mutations in keratins 1 and 10 cause epidermolytic hyperkeratosis.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Lane et al. 1985. Ann N Y Acad Sci. 455:241-58. PMID: 2417515.
  • •  Keratin antigens in differentiating skin.