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Contributor Information

  • Institute University of Illinois Chicago

Tool Details

  • Tool name: Anti-CUL-4A
  • Alternate names: CUL-4A
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Application: WB ; IP ; ChIP ; ELISA ; IHC
  • Description: CUL-4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. Moreover, CUL-4A is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a result, CUL-4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV.
  • Immunogen: Synthetic peptide (ERDKDNPNQYHYVA) (746-759, C-terminus peptide), corresponding to human CUL-4A was conjugated to maleimide-activated keyhole limpet hemocyanin
  • Research area: Cancer; Cell biology; Genetics; Biochemistry

  • For Research Use Only

Target Details

  • Target: Cullin 4A
  • Target background: CUL-4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. Moreover, CUL-4A is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a result, CUL-4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV.

Application Details

  • Application: WB ; IP ; ChIP ; ELISA ; IHC

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Sharma et al. 2014. Open Biol. 4:130217. PMID: 24522884.
  • •  Shiyanov et al. 1999. J Biol Chem. 274(50):35309-12. PMID: 10585395.