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Contributor Information

  • Name Keith Willison
  • Institute The Institute of Cancer Research

Tool Details

  • Tool name: Anti-CCT beta [PK/8/4/4i/2f]
  • Alternate names: CCT2; 99D8.1; CCT-beta; CCTB; PRO1633; TCP-1-beta; TCP1 Beta
  • Clone: PK/8/4/4i/2f
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Dog ; Hamster ; Human ; Mouse ; Pig ; Rat ; Rabbit ; Sheep
  • Host: Rat
  • Molecular weight of the target: 55 kDa
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.
  • Immunogen: TCP1 beta peptide conjugated to purified tuberculin protein derivative (PPD) (Mouse)
  • Isotype: IgG2b
  • Research area: Apoptosis and autophagy; Cancer; Cell biology; Immunology

  • For Research Use Only

Target Details

  • Target: Mouse CCT2 / CCT Beta
  • Target molecular weight: 55 kDa
  • Target background: This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Satish et al. 2010. Cell Stress Chaperones. 15(6):819-26. PMID: 20393890.
  • •  Cloning and expression of rabbit CCT subunits eta and beta in healing cutaneous wounds.
  • •  Fislov et al. 2010. J Virol. 84(17):8691-9. PMID: 20573828.
  • •  Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
  • •  Satish et al. 2010. PLoS One. 5(4):e10063. PMID: 20442790.
  • •  Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility.