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Contributor Information

  • Name Jacqueline Cordell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD11C [CD11C-100/D2]
  • Alternate names: Integrin Subunit Alpha X; Leukocyte Adhesion Glycoprotein P15;95 Alpha Chain; Complement Component 3 Receptor 4 Subunit; Leukocyte Adhesion Receptor P15;95; CD11 Antigen-Like Family Member C; CD11C
  • Clone: CD11C-100/D2
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IP ; WB
  • Description: The integrin alpha X chain protein (CD11c) belongs to the ?Ÿ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?Ÿ subunit. CD11c (the a subunit) combines with CD18 (the ?Ÿ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
  • Immunogen: Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK
  • Isotype: IgG2a
  • Research area: Cell biology; Cell signaling and signal transduction; Immunology; Stem cell biology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX
  • Target background: The integrin alpha X chain protein (CD11c) belongs to the ?Ÿ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?Ÿ subunit. CD11c (the a subunit) combines with CD18 (the ?Ÿ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Myones BL, et al., J Clin Invest. 1988 (2):640-51. PMID: 2969921 Bilsland et al., 1994. J. Immunol. 152(9):4582-9. PMID: 7512600 Ihanus E, et al., Blood. 2007 109(2):802-10. PMID: 16985175 Ammon C et al. Immunology. 2000. 100(3):364-9. PMID: 10929059