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Contributor Information

  • Name Lindy Durrant
  • Institute University of Nottingham

Tool Details

  • Tool name: Anti-CEA/NCA [198]
  • Alternate names: CEACAM5; CEA
  • Clone: 198
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC
  • Description: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.
  • Immunogen: CEA preparation purified from colon carcinoma metastases. Tumor subcellular membranes or viable cells from CEA-producing colon carcinoma cell lines
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CEA/NCA
  • Target background: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.

Application Details

  • Application: FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Reiterer et al. 2007. Cancer Res. 67(16):7765-72. PMID: 17699781.
  • •  Platelet-derived growth factor receptor regulates myeloid and monocytic differentiation of HL-60 cells.
  • •  Byers et al. 1988. J Immunol. 140(11):4050-5. PMID: 2453564.
  • •  Potentiation of anti-carcinoembryonic antigen immunotoxin cytotoxicity by monoclonal antibodies reacting with co-expressed carcinoembryonic antigen epitopes.