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Contributor Information

  • Name Mike Price
  • Institute University of Nottingham

Tool Details

  • Tool name: Anti-CEA [C365D3(NCRC23)]
  • Alternate names: CEACAM5; CEA; Carcinoembryonic Antigen
  • Clone: C365D3(NCRC23)
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 84 kDa
  • Application: ELISA ; FACS ; IHC
  • Description: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.
  • Immunogen: CEA
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: CD66e
  • Target molecular weight: 84 kDa
  • Target background: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins, found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily, CEA family- contains 7 Ig-like (immunoglobulin-like) domains.

Application Details

  • Application: ELISA ; FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Dallas et al. 2012. FASEB J. 26(6):2648-56. PMID: 22415308.
  • •  Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.
  • •  Durrant et al. 1989. J Natl Cancer Inst. 81(9):688-96. PMID: 2468779.
  • •  Flow cytometric screening of monoclonal antibodies for drug or toxin targeting to human cancer.
  • •  Durrant et al. 1987. Br J Cancer. 56(4):425-32. PMID: 3689659.
  • •  Quantitation of MHC antigen expression on colorectal tumours and its association with tumour progression.
  • •  Durrant et al. 1986. Cancer Res. 46(7):3543-9. PMID: 3518917.
  • •  Association of antigen expression and DNA ploidy in human colorectal tumors.
  • •  Durrant et al. 1986. Br J Cancer. 53(1):37-45. PMID: 3947514.
  • •  Antigenicity of newly established colorectal carcinoma cell lines.