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Contributor Information

  • Name Margaret Goodall
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-CD44 [BU75]
  • Alternate names: HCAM; homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; Hermes antigen; lymphocyte homing receptor; ECM-III; HUTCH-1.
  • Clone: BU75
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 90-95 kDa
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: The CD44 antigen is a cell-surface glycoprotein involved in cell to cell and cell-matrix interactions, cell adhesion and migration, which it achieves through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes.
  • Immunogen: Folicual dentritic cells and germinal centre B cells
  • Isotype: IgG2a
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Immunology

  • For Research Use Only

Target Details

  • Target: CD44
  • Target molecular weight: 90-95 kDa
  • Target background: The CD44 antigen is a cell-surface glycoprotein involved in cell to cell and cell-matrix interactions, cell adhesion and migration, which it achieves through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes.

Application Details

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
  • •  Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
  • •  Leucocyte Typing VII, (2002): edited by D.Y. Mason, OUP, Oxford.