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Contributor Information

  • Institute A*STAR Accelerate Technologies Pte Ltd

Tool Details

  • Tool name: Anti-CHIKV [3E7b]
  • Alternate names: Chikungunya virus
  • Clone: 3E7b
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: ELISA ; IHC ; Fn ; WB
  • Description: Monoclonal antibody capable of neutralising CHIKV replication and can detect infection of cells. Background and Research Application Chikungunya virus (CHIKV) is an alphavirus which causes febrile illness with severe polyarthralgia, known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4–7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhoea, vomiting and rash. CHIKV gained its infamy from the severe outbreak in the Indian Ocean island of La Re’union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced haemorrhagic fever manifestations. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa. Anti-CHIKV binds strongly to native CHIKV surface and potently neutralize CHIKV replication.
  • Immunogen: Live chikungunya virus
  • Immunogen UniProt ID: Q8JUX5
  • Isotype: IgM
  • Research area: Microbiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: N218 epitope on E2 protein of CHIKV
  • Target background: Monoclonal antibody capable of neutralising CHIKV replication and can detect infection of cells. Background and Research Application Chikungunya virus (CHIKV) is an alphavirus which causes febrile illness with severe polyarthralgia, known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4–7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhoea, vomiting and rash. CHIKV gained its infamy from the severe outbreak in the Indian Ocean island of La Re’union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced haemorrhagic fever manifestations. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa. Anti-CHIKV binds strongly to native CHIKV surface and potently neutralize CHIKV replication.

Application Details

  • Application: ELISA ; IHC ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Lam et al. 2015. MAbs. 7(6):1178-94. PMID: 26305993.