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Contributor Information

  • Name Julia Bodmer
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-HLA DP alpha [TAL3C3]
  • Clone: TAL3C3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 33 kDa
  • Application: IHC ; RIA ; WB
  • Strain: Balb/c
  • Description: Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products.
  • Immunogen: Bristol 8 separated alpha chain preparation
  • Isotype: IgG1
  • Research area: Immunology
  • Myeloma used: P3/NS1/1-Ag4-1

  • For Research Use Only

Target Details

  • Target: HLA DP alpha (DQ to a lesser extent)
  • Target molecular weight: 33 kDa
  • Target background: Human Leukocyte Antigens (HLA) are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 3C3 may be used for tissue typing on lymphoblastoid cells, transplantation typing, disease susceptibility and detection of class II products.

Application Details

  • Application: IHC ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Thomas et al. 1988. J Pathol. 154(4):353-63. PMID: 2455029.
  • •  HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.
  • •  Adams et al. 1983. Immunology. 50(4):613-24. PMID: 6197354.
  • •  Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.