ANTIBODIES

Contributor Information
- Name Roy Bicknell
- Institute University of Oxford
Tool Details
- Tool name: Anti-PDECGF [PGF 44C]
- Clone: PGF 44C
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 55 kDa (reduced)
- Application: IHC ; IF ; IP ; WB
- Description: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
- Immunogen: Full length human protein in E. coli
- Isotype: IgG1
- Research area: Cancer; Tissue-specific biology; Immunology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF.
- Target molecular weight: 55 kDa (reduced)
- Target background: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
Application Details
- Application: IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15ðC to -25ðC
- Shipping conditions: Shipping at 4ðC
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References
- • Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.
- • Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.
- • Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.
- • Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.
- • Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
- • DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
- • Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.
- • Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.
- • Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.
- • Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
- • Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.
- • Thymidine phosphorylase is angiogenic and promotes tumor growth.