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Contributor Information

  • Name Roy Bicknell
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-PDECGF [PGF 44C]
  • Clone: PGF 44C
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 55 kDa (reduced)
  • Application: IHC ; IF ; IP ; WB
  • Description: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
  • Immunogen: Full length human protein in E. coli
  • Isotype: IgG1
  • Research area: Cancer; Tissue-specific biology; Immunology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF.
  • Target molecular weight: 55 kDa (reduced)
  • Target background: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

References

  •   Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.
  •   Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.
  •   Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.
  •   Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.
  •   Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
  •   DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
  •   Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.
  •   Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.
  •   Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.
  •   Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
  •   Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.
  •   Thymidine phosphorylase is angiogenic and promotes tumor growth.