ANTIBODIES
Contributor Information
- Name Helen Turley
- Institute University of Oxford
Tool Details
- Tool name: Anti-JMY [HMY117]
- Clone: HMY117
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IHC ; WB
- Description: The anti-JMY [HMY117] antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. It might act either as tumor suppressor or as oncogene. This antibody may be used in research but also as a diagnostic tool.
- Immunogen: Synthetic peptide from the c terminus of the peptide sequence, identical for both isoform 1 and 2
- Isotype: IgG1
- Research area: Apoptosis and autophagy
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: JMY
- Target background: The anti-JMY [HMY117] antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. It might act either as tumor suppressor or as oncogene. This antibody may be used in research but also as a diagnostic tool.
Application Details
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
References
- • Adighibe et al. 2014. Virchows Arch. 465(6):715-22. PMID: 25280461.
- • JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
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