Product Image

Contributor Information

  • Name Peter Beverley
  • Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Leu1 [UCH-T2]
  • Clone: rUCH-T2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF ; WB
  • Description: Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
  • Immunogen: Thymocytes followed by Sezary T cells.
  • Isotype: IgG2a
  • Research area: Immunology; Stem cell biology

  • For Research Use Only

Target Details

  • Target: Leu1 (CD5)
  • Target background: Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.

Application Details

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Homogalacturonan [JIM7]

#157925
Product Image

Anti-MUS81 [MTA30 2G10/3]

#151291
Product Image

Anti-DNA [m165-41]

#157822

References

  • •  Original hybridoma first published in: Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
  • •  Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.