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Contributor Information

  • Name Stephen West
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-MUS81 [MTA30 2G10/3]
  • Clone: MTA30 2G10/3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 60-65 kDa
  • Application: IF ; ICC ; FACS ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: MUS81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.
  • Immunogen: Human MUS81
  • Isotype: IgG2a
  • Research area: Cancer; Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: MUS81
  • Target molecular weight: 60-65 kDa
  • Target background: MUS81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes.

Application Details

  • Application: IF ; ICC ; FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Xu et al. 2019. Sci Adv. 5(10):eaax6366. PMID: 31633027.
  • •  Panier et al. 2019. Mol Cell. 76(1):27-43.e11. PMID: 31447390.
  • •  Mason et al. 2019. Nat Commun. 10(1):4410. PMID: 31562309.
  • •  Xu et al. 2017. Elife. 6:. PMID: 29106372.
  • •  Moder et al. 2017. Nat Commun. 8(1):1238. PMID: 29089570.
  • •  Lemaon et al. 2017. Nat Commun. 8(1):860. PMID: 29038425.
  • •  Li et al. 2017. Mol Med Rep. 16(4):5321-5325. PMID: 28849153.
  • •  Dungrawala et al. 2017. Mol Cell. 67(3):374-386.e5. PMID: 28735897.
  • •  Di Marco et al. 2017. Mol Cell. 66(5):658-671.e8. PMID: 28575661.
  • •  Lv et al. 2017. Tumour Biol. 39(3):1010428317694307. PMID: 28347251.
  • •  Wyatt et al. 2017. Mol Cell. 65(5):848-860.e11. PMID: 28257701.
  • •  Meisenberg et al. 2017. Nucleic Acids Res. 45(3):1159-1176. PMID: 28180300.
  • •  Meisenberg et al. 2017. Nucleic Acids Res. 45(3):1159-1176. PMID: 28180300.
  • •  Jo et al. 2016. PLoS Genet. 12(12):e1006465. PMID: 27906959.
  • •  Pepe et al. 2014. Nucleic Acids Res. 42(6):3833-45. PMID: 24371268.
  • •  CtIP is required to initiate replication-dependent interstrand crosslink repair.
  • •  Duquette et al. 2012. PLoS Genet. 8(11):e1003050. PMID: 23144634.
  • •  Svendsen et al. 2009. Cell. 138(1):63-77. PMID: 19596235.
  • •  Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
  • •  Franchitto et al. 2008. J Cell Biol. 183(2):241-52. PMID: 18852298.
  • •  Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.