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Contributor Information

  • Institute A*STAR Accelerate Technologies Pte Ltd

Tool Details

  • Tool name: Anti-CXCL16 [4.4]
  • Clone: 4.4
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; WB
  • Description: CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes. This membrane-bound CXCL16 is expressed in antigen-presenting cells such as monocytes, macrophages, B cells and dendritic cells in the T-cell zone of lymph nodes, whereas the soluble CXCL16 can be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, coronary artery disease and liver injury.
  • Immunogen: GST-CXCL16 (143-224aa) fusion protein
  • Isotype: IgG1 kappa
  • Research area: Tissue-specific biology; Immunology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: C-X-C motif chemokine 16
  • Target background: CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes. This membrane-bound CXCL16 is expressed in antigen-presenting cells such as monocytes, macrophages, B cells and dendritic cells in the T-cell zone of lymph nodes, whereas the soluble CXCL16 can be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, coronary artery disease and liver injury.

Application Details

  • Application: IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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