Product Image

Contributor Information

  • Name Gavin Wright
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Zebrafish DeltaC [zdc2]
  • Clone: zdc2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Zebrafish
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.
  • Immunogen: Extracellular region of zebrafish DeltaC protein
  • Isotype: IgG2a
  • Research area: Cell biology; Developmental biology; Neurobiology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Zebrafish DeltaC
  • Target background: Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.

Application Details

  • Application: ELISA ; FACS ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-ADAM12 [12MO]

#152531
Product Image

Anti-TNC-C [4H7.1]

#160464
Product Image

Anti- S. pneumoniae serotype 14 capsule (polysaccharide) [5C7]

#153698

References

  • •  Gallagher et al. 2017. Dev Biol. 429(1):225-239. PMID: 28648842.
  • •  Quillien et al. 2014. Development. 141(7):1544-52. PMID: 24598161.
  • •  Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612.
  • •  DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock.
  • •  Giudicelli et al. 2007. PLoS Biol. 5(6):e150. PMID: 17535112.
  • •  Setting the tempo in development: an investigation of the zebrafish somite clock mechanism.