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Contributor Information

  • Name Martin Rowe
  • Institute University of Birmingham

Tool Details

  • Tool name: Anti-EBV Latent Membrane Protein 1 [LMPO24]
  • Clone: LMPO24
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: FACS ; IHC
  • Strain: Balb/c
  • Description: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
  • Immunogen: Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus
  • Immunogen UniProt ID: P03230
  • Isotype: IgG1 kappa
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Immunology; Microbiology

  • For Research Use Only

Target Details

  • Target: Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
  • Target background: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.

Application Details

  • Application: FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.
  • •  Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.