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Contributor Information

  • Name Joyce Taylor-Papadimitriou
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-Keratin19 [BA17]
  • Clone: BA17
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IP ; WB
  • Strain: Balb/c
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.
  • Immunogen: Detergent-insoluble extract of human mammary epithelial organoids.
  • Isotype: IgG1
  • Research area: Cell signaling and signal transduction
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Keratin 19
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.

Application Details

  • Application: FACS ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Morton et al. 2008. Am J Pathol. 172(4):1081-7. PMID: 18310506.
  • •  Trp53 deletion stimulates the formation of metastatic pancreatic tumors.
  • •  Aleksic et al. 2007. Gut. 56(2):227-36. PMID: 16870717.
  • •  Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2.
  • •  Nightingale et al. 2004. J Am Soc Nephrol. 15(1):21-32. PMID: 14694154.
  • •  Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation.
  • •  Brtek et al. 1986. Eur J Cancer Clin Oncol. 22(12):1441-52. PMID: 2439341.
  • •  Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells.
  • •  Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.
  • •  Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.
  • •  Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.
  • •  A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.