Product Image

Contributor Information

  • Name Gillian Murphy ; Christopher Tape
  • Institute Absolute Antibody ; Cancer Research UK Cambridge Institute

Tool Details

  • Tool name: Anti-TACE [D1 (A12)] (mouse IgG)
  • Clone: rD1 (A12)
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Neurological cancer; Genitourinary cancer; Liver cancer; Lung
  • Application: Fn
  • Description: TACE (CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, TACE has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis. This “cross-domain” human antibody is a selective TACE antagonist and provides a unique alternative to smallmolecule metalloprotease inhibition.
  • Immunogen: Recombinant human ADAM17 (TACE) ectodomain tagged to biotin.
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction; Metabolism; Neurobiology; Stem cell biology

  • For Research Use Only

Target Details

  • Target: TACE (ADAM17)
  • Target background: TACE (CD156b) has proved capable of cleaving epidermal growth factor receptor (EGFR) ligands, extracellular Notch1, cell-surface receptors, and adhesion molecules. As proteolytic cleavage is an indispensable activation event for many of these substrates, TACE has emerged as an attractive therapeutic target for the treatment of cancer and rheumatoid arthritis. This cross-domain human antibody is a selective TACE antagonist and provides a unique alternative to smallmolecule metalloprotease inhibition.

Application Details

  • Application: Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS only
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-cMyc [PM3E7]

#152697
Product Image

Anti-Extensin [JIM12]

#157944
Product Image

Anti-PCNA [PC8]

#151151

References

  • •  Original antibody first published in Tape et al. 2011. Proc Natl Acad Sci U S A. 108(14):5578-83. PMID: 21415364.
  • •  Cross-domain inhibition of TACE ectodomain.