Product Image

Contributor Information

  • Name Joyce Taylor-Papadimitriou ; Joy Burchell
  • Institute Absolute Antibody ; Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-MUC1 [SM3]
  • Alternate names: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
  • Clone: rSM3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Breast cancer; Gynaecologic cancer; Digestive / Gastrointestinal cancer;
  • Application: ELISA ; FACS ; IHC
  • Description: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
  • Immunogen: Hydrogen fluoride deglycosylated milk mucin.
  • Isotype: IgG1
  • Research area: Cancer; Cell biology; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: Mucin1 (MUC1)
  • Target background: MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.

Application Details

  • Application: ELISA ; FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS only
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-Gamma-Sarcoglycan [35DAG/21B5]

#153727
Product Image

Anti-DNA Ligase 1 [7A12]

#152694
Product Image

Anti-Cytokeratin [PK141]

#151395

References

  • •  Original hybridoma first published in Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.
  • •  Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.