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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-DNA Ligase 1 [7A12]
  • Clone: 7A12
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bovine ; Human
  • Host: Mouse
  • Molecular weight of the target: 125 kDa
  • Application: WB ; ELISA ; IHC ; IP ; WB
  • Strain: Balb/c
  • Description: DNA ligase 1 is involved in DNA replication and the nucleotide excision repair pathway.
  • Immunogen: Bovine DNA Ligase I
  • Isotype: IgG1
  • Research area: Genetics
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: DNA Ligase 1
  • Target molecular weight: 125 kDa
  • Target background: DNA ligase 1 is involved in DNA replication and the nucleotide excision repair pathway.

Application Details

  • Application: WB ; ELISA ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Liang et al. 2008. Nucleic Acids Res. 36(10):3297-310. PMID: 18440984.
  • •  Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks.
  • •  Prigent et al. 1994. Mol Cell Biol. 14(1):310-7. PMID: 8264597.
  • •  Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.