ANTIBODIES
Contributor Information
- Name Roland Wolf
- Institute University of Dundee
Tool Details
- Tool name: Anti-Cytochrome P450 2A6 [CYP2A6]
- Clone: CYP2A6
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Sheep
- Application: WB
- Description: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
- Immunogen: Purified recombinant human P450s
- Research area: Cancer; Tissue-specific biology; Cell signaling and signal transduction; Genetics; Metabolism
- For Research Use Only
Target Details
- Target: Cytochrome P450 2A6, CYP2A6
- Target background: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
Application Details
- Application: WB
Handling
- Format: Liquid
- Storage conditions: -80Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
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